GLP-1 therapy is a type of treatment used for managing weight and blood sugar levels in individuals with type 2 diabetes and obesity. How GLP-1 works is by mimicking the effects of the natural hormone GLP-1, which helps to regulate insulin production and decrease glucose production in the liver.
There are different types of GLP-1 therapies available, including injectable medications and oral tablets to even probiotic support supplements that help with the release of GLP-1. These options provide flexibility for individuals who may have preferences or aversions to certain methods of administration.
However, as we always advise here at Genesis Supplements, it’s important to consult with a healthcare professional first to determine which type of GLP-1 therapy is right for you based on your individual needs and medical history.
If you are intrigued to learn more about certain types of GLP-1 for diabetics and overweight people or the common side effects of traditional GLP-1 shots and discover the best option for you, continue reading this blog and scroll down below.
Quick Review on GLP-1
Known as glucagon-like peptide-1 (GLP-1), is a hormone produced in the intestines that helps regulate blood sugar levels by stimulating insulin release and reducing glucagon production. It also helps to slow down digestion, leading to a feeling of fullness and reduced appetite.
GLP-1 and Diabetes
For individuals with type 2 diabetes, their bodies may not produce enough GLP-1 or may not respond to it effectively. That is why GLP-1 therapy is needed. By providing synthetic forms of GLP-1, either through injections or oral medications, individuals can better regulate their blood sugar levels and potentially lose weight.
This type of therapy can be especially beneficial for those who have not responded well to other traditional diabetes medications or who struggle with weight management.
GLP-1 and Weight Loss
Traditional GLP-1 medications have been shown to cause weight loss, but not all of them are approved for official use in weight loss treatment. However, there are different brands of GLP-1 medications that have been specifically approved for weight loss.
These medications have been developed and tested to specifically target weight loss, providing options for individuals seeking effective and approved treatments for weight management.
GLP-1 and Probiotic Support
In recent years, pharmaceutical companies have developed medications that mimic the effects of GLP-1, leading to significant weight loss in some patients. One of the latest developments in the world of weight loss medications is the inclusion of GLP-1 probiotic support supplements as approved treatments and now one of the choices in GLP-1 therapy.
These GLP-1 support supplements work by helping to produce the GLP-1 hormone, the same as how traditional and synthetic GLP-1 works. However, the problem with the traditional GLP-1s have strict criteria, and not everyone can gain access to them.
Exploring the Top GLP-1 Therapies
GLP-1 receptor agonists or GLP-1 therapies are a type of medication used to treat type 2 diabetes. These therapies work by stimulating insulin production and reducing the production of glucagon, a hormone that raises blood sugar levels.
Some common generic GLP-1 therapies include benefits [1]:
- Semaglutide: Administered once weekly and has been shown to significantly reduce A1C levels in clinical trials.
- Dulaglutide: Administered once weekly and has been proven to reduce the risk of MACE (cardiovascular events) in patients with diabetes.
- Liraglutide: Administered once daily and has been shown to help patients achieve better blood sugar control and weight loss.
- Exenatide: Administered twice daily and is effective in lowering blood sugar levels and promoting weight loss in patients with type 2 diabetes.
- Tirzepatide: A newer generic therapy for type 2 diabetes that works by increasing insulin secretion and decreasing glucagon production. [2]
GLP-1 treatments are all available under various brand names for different purposes. These brand names are used to differentiate the same medication when used for different conditions, making it easier for healthcare providers and patients to identify and prescribe the appropriate treatment. Individuals need to be aware of the different brand names associated with GLP-1 therapy to ensure they are receiving the correct medication for their specific health needs.
Which GLP-1 Therapy is the Best for Diabetics?
All these generic GLP-1 meds worked well in tests and clinical trials, however, healthcare providers consider various factors to determine which brand is the most suitable option. Factors such as individual patient needs, medical history, and potential side effects are carefully evaluated to finally end up with a decision.
For diabetic people, these are the best brands you can go with. They are all approved for type 2 diabetes treatment however they are not approved for weight loss treatments even if they show definite effects of losing weight to the people taking it.
1. Ozempic
Ozempic is approved for type 2 diabetes and cardiovascular risk reduction, making it a versatile treatment option for those with these conditions. This semaglutide once-a-week injection schedule offers convenience, reducing the burden of daily medication management commonly associated with other treatments.
In addition to its primary function of blood sugar control, Ozempic has been shown to aid in weight management. Studies have indicated that patients using Ozempic experienced greater weight loss compared to those on oral medications alone.
2. Rybelsus
Rybelsus, another brand for semaglutide, is an oral GLP-1 therapy designed for individuals with type 2 diabetes. It offers the convenience of being taken once daily, simplifying the treatment regimen and enhancing patient adherence. This ease of use can be particularly beneficial for individuals who may struggle with injectable medications or complex dosing schedules.
Moreover, Rybelsus provides flexibility as it can be used as a standalone treatment (monotherapy) or in combination with other diabetes medications. This versatility allows healthcare providers to tailor the treatment plan to each patient’s specific needs, which is crucial in managing a complex condition like type 2 diabetes.
By offering an oral option for GLP-1 therapy, Rybelsus addresses potential barriers related to injections and administration complexity that some patients may encounter with traditional injectable GLP-1 therapies. The availability of different administration routes contributes to improving overall patient satisfaction and long-term treatment compliance.
3. Trulicity
Trulicity is a dulaglutide that has a once-weekly injectable treatment specifically designed for individuals with type 2 diabetes. It has been proven to effectively lower A1C levels, which is crucial in managing blood sugar levels and reducing the risk of diabetes-related complications.
It has demonstrated its potential in reducing the risk of major adverse cardiovascular events (MACE). This aspect is particularly noteworthy given that individuals with type 2 diabetes are at an increased risk of cardiovascular issues.
4. Victoza
The liraglutide, Victoza, is a medication used to enhance blood sugar control in adults diagnosed with type 2 diabetes. Administered through a daily injection, it offers convenience and effectiveness for managing blood glucose levels.
This GLP-1 receptor has demonstrated a low risk of hypoglycemia compared to certain other antidiabetic medications. This characteristic enhances its safety profile and minimizes the likelihood of experiencing dangerously low blood sugar levels while using this medication.
5. Byetta
Byetta is a medication administered by injection twice daily before meals to enhance blood sugar control in adults with type 2 diabetes. This exenatide stimulates insulin release and inhibits glucagon secretion after meals, thereby assisting in the regulation of blood sugar levels.
Byetta can aid in reducing postprandial glucose levels, which refers to the blood sugar levels after eating. This is particularly beneficial for individuals with type 2 diabetes as it helps in managing their condition effectively.
Byetta’s impact on appetite regulation has also been observed. It works as the GLP-1 hormone, affecting the gastrointestinal system to slow down gastric emptying and reduce food intake.
6. Bydureon BCise
Bydureon BCise is a weekly injectable medication designed for adults with type 2 diabetes. It is another type under exenatide that not only helps lower A1C levels but also supports weight loss, addressing two critical aspects of diabetes mellitus management simultaneously.
The convenience of a once-weekly dosing schedule sets Bydureon BCise apart, offering patients a simpler and more manageable treatment routine compared to daily medications. Its weekly administration may contribute to reduced discontinuation rates compared to daily or multiple-dose regimens.
7. Mounjaro
Mounjaro is an investigational GLP-1 receptor agonist specifically designed for the treatment of type 2 diabetes. It is a tirzepatide that aims to provide effective glycemic control and potentially offer cardiovascular benefits, addressing crucial aspects of diabetes management.
Ongoing clinical trials are currently underway to evaluate the safety and efficacy of Mounjaro. These trials play a pivotal role in determining the drug’s viability as a treatment option for individuals with type 2 diabetes.
The progression of this investigational therapy reflects the continuous efforts within the medical community to advance treatment options for individuals living with type 2 diabetes, showcasing a commitment to enhancing patient care and quality of life.
Which GLP-1 Therapy is the Best for Obesity?
These innovative therapies hold promise in offering improved outcomes for patients struggling with type 2 diabetes by providing better control over blood sugar levels while also potentially benefiting cardiovascular health.
For obese people who have other weight management problems, some GLP-1 brands are FDA-approved for official weight loss use is the best option for you.
8. Wegovy
Wegovy, an FDA-approved treatment for chronic weight management in adults with obesity, has shown significant efficacy in aiding weight loss when compared to a placebo. Clinical trials have demonstrated that individuals using Wegovy experienced substantial weight reduction over a period of time.
Moreover, apart from its impact on weight, this semaglutide therapy has been found to improve various cardiometabolic risk factors. This means that alongside shedding excess pounds, individuals undergoing treatment with Wegovy may also experience positive changes in their overall health profile.
The approval of Wegovy by the FDA marks a milestone in the field of obesity management as it provides healthcare professionals and patients with another viable option for addressing this complex condition.
9. Saxenda
Saxenda is indicated for chronic weight management along with a reduced-calorie diet and increased physical activity. This injectable medication, administered once daily, plays a pivotal role in promoting sustainable weight loss. It is effective in aiding body weight reduction when used as part of a comprehensive weight loss program.
As a liraglutide, Saxenda may offer additional benefits beyond just weight reduction. In clinical trials, participants using Saxenda experienced significant average weight loss compared to the placebo group. This demonstrates its potential to contribute positively to treatment satisfaction and overall well-being for those struggling with chronic overweight or obesity.
The use of Saxenda can also lead to improvements in body mass index (BMI), which is crucial for gauging progress in managing excess body weight effectively over time.
10. Zepbound
Zepbound is a tirzepatide GLP-1 therapy that was just approved by the US FDA for official weight loss. It aims to provide improved weight loss outcomes compared to existing treatments, offering hope for individuals struggling with obesity. [2]
Preclinical studies have shown promising results in the regulation of appetite and metabolism. This suggests that Zepbound has the potential to address the root causes of obesity by impacting factors like peptide levels, ultimately leading to more effective weight management.
The impact of Zepbound could represent a significant advancement in addressing one of the most pressing public health concerns globally – the rising rates of obesity. With its unique mechanism of action and potential for enhanced weight loss outcomes, it could be a candidate that holds promise for improving the lives of millions affected by obesity.
GLP-1 Probiotic Support: The Best GLP-1 Therapy Partner
Probiotics are live microorganisms that provide health benefits when consumed in adequate amounts. They work by promoting a healthy balance of gut bacteria, which can have a significant impact on various aspects of health, including metabolism and hormone regulation.
When it comes to GLP-1 therapy, probiotics play a crucial role in supporting the function of GLP-1. By promoting the growth of beneficial gut bacteria, probiotics can enhance the production and effectiveness of GLP-1, making it an ideal therapy for individuals looking to improve their metabolic health.
This combination of probiotics and GLP-1 therapy offers a natural and effective way to support overall wellness and manage conditions such as diabetes and obesity. While these supplements are not a magic solution for everyone, they have shown promising results in clinical trials and have been approved by regulatory agencies for use in weight management.
How Probiotics and GLP-1 are Connected?
Probiotics and GLP-1 are connected through the gut-brain axis. When probiotics are consumed, these living microorganisms provide health benefits that influence the production of GLP-1 hormones in the gut.
Studies have shown that certain strains of probiotics can increase the production of GLP-1, which can have positive effects on metabolism and overall health. This connection between probiotics and GLP-1 highlights the potential for using probiotics as a way to support metabolic health and potentially manage weight problems and blood sugar levels.
Gut Microbiota Balance
Introducing probiotics can help maintain a healthy balance of gut microbiota, which is essential for optimizing the response to GLP-1 therapy. Studies have shown that an imbalance in gut bacteria can impact the efficacy of GLP-1 receptor agonists.
Improved Glucose Control
Probiotics have been linked to improved glucose control, which complements the effects of GLP-1 therapy. Research suggests that specific strains of probiotics may contribute to better glycemic control and insulin sensitivity, ultimately supporting the goals of GLP-1 treatment. [3]
Anti-inflammatory Effects
Certain probiotics exhibit anti-inflammatory properties, which can be beneficial for individuals undergoing GLP-1 therapy. By reducing inflammation in the gut, probiotics may enhance the overall metabolic benefits associated with GLP-1 receptor agonists.
Enhanced Nutrient Absorption
Probiotics are known to promote optimal nutrient absorption in the digestive system. This is particularly relevant for individuals utilizing GLP-1 therapy as it ensures that nutrients vital for metabolic regulation are efficiently absorbed and utilized by the body.
Takeaways
Whether it’s Ozempic, Rybelsus, Wegovy, Trulicity, Victoza, Saxenda, Byetta, Bydureon BCise, Mounjaro, or Zepbound, your choice of GLP-1 therapy should align with your specific needs and lifestyle. Plus, all of these GLP-1 therapies could work much better if paired with a probiotic support.
We already know that GLP-1 production could be better if backed up by good probiotic intake. That’s why Genesis Supplements has recently launched a new product that could help with your weight loss journey.
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Frequently Asked Questions
Which GLP-1 therapy may be best for me?
The choice of the best GLP-1 therapy depends on various factors such as individual health conditions, lifestyle preferences, and treatment goals. However, if you are looking to remedy the root cause of all these, start with supporting your probiotic intakes first as having the adequate probiotics will have a domino effect on your GLP-1 hormone production. Genesis Supplements Korbiotics is the most affordable and easily accessible over-the-counter probiotic supplement that could help with your weight loss. Consulting with a healthcare professional can help determine the most suitable option based on your specific needs.
Can probiotics support GLP-1 therapy?
Probiotics may potentially play a supportive role in GLP-1 therapy by influencing gut microbiota composition. Research suggests that certain probiotic strains could enhance the beneficial effects of GLP-1-based treatments on metabolic health. However, further studies are needed to confirm these findings.
Are there any potential side effects associated with using GLP-1 therapy?
Common side effects of traditional GLP-1 therapy may include nausea, vomiting, diarrhea, or constipation. In some cases, hypoglycemia (low blood sugar) can occur if combined with insulin or sulfonylureas. It’s important to discuss potential side effects with your healthcare provider before starting any medication.
References:
[1] J. Adkison, “Comparing Ozempic, Wegovy and Other GLP-1 Drugs,” GoodRx, Dec. 07, 2022. https://www.goodrx.com/classes/glp-1-agonists/glp-1-drugs-comparison
[2] “FDA Approves Lilly’s ZepboundTM (tirzepatide) for Chronic Weight Management, a Powerful New Option for the Treatment of Obesity or Overweight with Weight-Related Medical Problems | Eli Lilly and Company,” Eli Lilly and Company, 2022. https://investor.lilly.com/news-releases/news-release-details/fda-approves-lillys-zepboundtm-tirzepatide-chronic-weight
[3] E. Yefet et al., “Effects of Probiotics on Glycemic Control and Metabolic Parameters in Gestational Diabetes Mellitus: Systematic Review and Meta-Analysis,” Nutrients, vol. 15, no. 7, p. 1633, Mar. 2023, doi: https://doi.org/10.3390/nu15071633.